منابع مشابه
Low dose hypersensitivity after high-LET irradiation
An unexpected hypersensitivity has been reported for several cell lines at low doses (<1Gy), which is not consistent with the linear-quadratic approach currently used in general for the description of survival curves [1,2,3,4]. The corresponding substructure of the survival curves has been attributed to induced radioresistance. There are indications, that high-LET irradiation with neutron or pi...
متن کاملLow Dose Cranial Irradiation-Induced Cerebrovascular Damage Is Reversible in Mice
BACKGROUND High-dose radiation-induced blood-brain barrier breakdown contributes to acute radiation toxicity syndrome and delayed brain injury, but there are few data on the effects of low dose cranial irradiation. Our goal was to measure blood-brain barrier changes after low (0.1 Gy), moderate (2 Gy) and high (10 Gy) dose irradiation under in vivo and in vitro conditions. METHODOLOGY Cranial...
متن کاملDrosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation.
Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage. Our data indicate that both ATM and its regulator Mre11 are important for the checkpoint and that their roles become essential when animals are challenged with a low dose of X rays or ...
متن کاملLow-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS.
Skin cancer is one of the most common types of malignancy in the world. UV radiation is known as the primary environmental carcinogen responsible for skin cancer development. However, UV radiation is a ubiquitous substance existing in the environment and the physiological effect of UV radiation is consistently ignored. Therefore, in the present study, the physiological effect of UV radiation on...
متن کاملAlteration of Genome Structure Induced by Very Low Dose-Rate Irradiation in Mouse Tissues
ABSTRACT To understand the effects of low dose-rate radiation on genome structure in vivo, we examined gene mutation and chromosomal abnormality in mouse tissues. The mutation was studied on transgenes in the spleen and liver and also on the Dlb1 gene in intestinal stem cells. The mice were irradiated for 483 consecutive days at three dose-rates of 0.0323, 0.65, and 12.5 μGy/min, which resulted...
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ژورنال
عنوان ژورنال: Open access journal of biomedical science
سال: 2021
ISSN: ['2690-487X']
DOI: https://doi.org/10.38125/oajbs.000276